Macrocyclic peptides that inhibit Wnt signallingviainteraction with Wnt3a
نویسندگان
چکیده
منابع مشابه
Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein–Protein Interactions
Macrocyclic peptides can interfere with challenging biomolecular targets including protein-protein interactions. Whereas there are various approaches that facilitate the identification of peptide-derived ligands, their evolution into higher affinity binders remains a major hurdle. We report a virtual screen based on molecular docking that allows the affinity maturation of macrocyclic peptides t...
متن کاملCorrection to Macrocyclic β-Sheet Peptides That Inhibit the Aggregation of a Tau-Protein-Derived Hexapeptide
The captions for Figure 2C,D have several minor errors numbering of the residues of Aβ. The corrected captions should read: (C) NMR-based structural model of Aβ1−40 fibrils showing central residues K16−D22 and A30−V36. (D) NMR-based structural model of Aβ1−42 fibrils showing central residues L17−I41. These errors are peripheral to this paper and do not affect the results or conclusions in any way.
متن کاملMacrocyclic β-Sheet Peptides That Inhibit the Aggregation of a Tau-Protein-Derived Hexapeptide
This paper describes studies of a series of macrocyclic β-sheet peptides 1 that inhibit the aggregation of a tau-protein-derived peptide. The macrocyclic β-sheet peptides comprise a pentapeptide "upper" strand, two δ-linked ornithine turn units, and a "lower" strand comprising two additional residues and the β-sheet peptidomimetic template "Hao". The tau-derived peptide Ac-VQIVYK-NH(2) (AcPHF6)...
متن کاملNovel Peptides that Block the Interaction between Wnt and Frizzled
Wnt/Frizzled signaling is involved in many developmental processes but is mostly silent in healthy adult organs. However, a reactivation of this signaling pathway is generally observed during pathological conditions, which makes it a promising therapeutic target. The recently presented crystal structure of Xenopus Wnt8 in complex with the cysteine rich domain (CRD) of Frizzled8 demonstrates tha...
متن کاملShort constrained peptides that inhibit HIV-1 entry.
Peptides corresponding to the C-terminal heptad repeat of HIV-1 gp41 (C-peptides) are potent inhibitors of HIV-1 entry into cells. Their mechanism of inhibition involves binding in a helical conformation to the central coiled coil of HIV-1 gp41 in a dominant-negative manner. Short C-peptides, however, have low binding affinity for gp41 and poor inhibitory activity, which creates an obstacle to ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: RSC Chemical Biology
سال: 2020
ISSN: 2633-0679
DOI: 10.1039/d0cb00016g